Mechanistically, TXNIP antagonizes Trx1 by forming a disulfide bond with its Cys32 residue, leading to Trx1 inactivation and increased ROS levels, thereby facilitating lipid peroxidation and ferroptotic signaling
The onset of the LEC fibrotic response after lens injury The transcriptional changes induced in LECs within 6 hours of lens injury in mice subjected to lens fiber cell removal surgery do not include fibrotic markers associated with LEC conversion to myofibroblasts (61)
Even though variable GSH concentrations were not tested, the authors suggested that Lys19 replacements have a negative effect on the reactivity of the glutathionylated enzyme with the reducing agent
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